In 2025, the cyber threat landscape shifted dramatically as ransomware and supply chain attacks reached unprecedented levels, showing cybercriminals are finding new ways to disrupt business operations and extract massive payouts.
According to Cyble’s 2025 ransomware and supply chain threat analysis, organizations faced 6,604 ransomware attacks, a 52% jump from 2024, while supply chain incidents nearly doubled with 297 events claimed by threat actors last year.
This surge underscores a harsh reality: traditional “detect and respond” strategies are not enough. Business owners must adopt isolation and containment approaches like AppGuard to truly mitigate these evolving threats.
Ransomware groups are no longer static or predictable. Cyble’s analysis highlights how previously dominant groups like RansomHub disappeared while new actors such as Qilin, Sinobi, and The Gentlemen emerged rapidly in 2025, exploiting vulnerabilities and targeting a broad range of sectors. These attackers are not just encrypting systems; they are innovating and finding new entry points for maximum impact.
Attack volumes increased sharply, with nearly 731 ransomware incidents in December alone.
Over 350 new ransomware strains were discovered, making signature-based detection less reliable.
Critical infrastructure industries, including energy, government, and technology, have been aggressively targeted.
For business owners, the proliferation of ransomware variants and threat actors makes it clear: relying solely on detection after compromise is a losing strategy.
Even more concerning is how ransomware and supply chain attacks are becoming intertwined. Supply chain attacks surged in 2025, nearly doubling over the previous year as malicious actors infiltrated trusted software vendors, service providers, and third parties to reach high-value targets.
These attacks exploit trust relationships and the growing complexity of vendor ecosystems:
IT and Technology sectors accounted for more than a third of all supply chain attacks, hitting every tracked industry.
Adversaries weaponized common channels such as SaaS integrations, identity providers, and package delivery systems to pivot deeper into networks.
Recent cases outside this report confirm the danger. For example, the Japanese retailer Muji had to halt online sales after a ransomware attack on its logistics provider disrupted operations and customer service.
These supply chain breaches show how even robust internal defenses can be bypassed when a trusted partner is compromised. If a vendor with weak security becomes the conduit for ransomware, the impact can ripple through an entire ecosystem.
Most traditional cybersecurity tools focus on identifying threats after they occur. But with ransomware strains evolving daily and supply chain attacks exploiting trusted connections, detection alone delivers only reactive protection.
Detection tools may miss novel ransomware variants until after damage is done.
Alert fatigue and false positives can slow incident response times.
Once attackers have executed their payload, it is often too late to stop the damage.
Instead, organizations must shift their mindset to proactive isolation and containment, preventing unknown threats from gaining a foothold in the first place.
AppGuard uses a fundamentally different approach. Rather than waiting to detect malicious behavior, it blocks unknown or unauthorized actions through isolation, preventing ransomware and other malware from executing harmful operations.
This method stops attacks regardless of signature or threat intelligence updates, making it especially effective against:
Zero-day exploits
Living-off-the-land techniques
Supply chain intrusion attempts
Rapidly mutating ransomware strains
With a 10-year track record of success, AppGuard has protected organizations across industries. Its isolation model stops threats at the endpoint before they can disrupt operations or encrypt data.
The evidence from 2025 is clear. Ransomware and supply chain attacks are escalating in both frequency and sophistication. Businesses that rely solely on traditional “detect and respond” defenses risk costly downtime, data loss, and reputational damage.
Now is the time to rethink endpoint security.
Business owners: talk with us at CHIPS about how AppGuard can prevent the type of incidents outlined in Cyble’s ransomware and supply chain threat landscape report. Move beyond detection to true isolation and containment. Let’s protect your business and your partners with a proven, proactive defense strategy that stops attacks before they start.
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